The 2nd International Conference on Signal Processing and Machine Learning (CONF-SPML 2022) was held online from May 12 to 18, 2022. The accepted papers were published in CEUR Workshop Proceedings (ISSN: 1613-0073). Prof. Alex Siow from the National University of Singapore, Prof. David P. Woodruff from Carnegie Mellon University, and Prof. Naira Hovakimyan from UIUC have given keynote speeches on related topics of AI/ML in business, adversarially robust streaming algorithms, and intelligent agricultural management. Also, we invited authors of qualified papers to deliver oral presentations at the online session. 2 authors have presented their studies of machine learning and convolutional neural network. Questions from the audience were collected and answered by the presenters. This conference provided the participants with good opportunities to exchange ideas and build networks, and it will lead to further collaborations between both universities and other societies.